GENERAL INFORMATION

Trade name of the drug: Depolac.
International Nonproprietary Name: Cloxacillin, Neomycin.
Dosage Form: Suspension for Intra-cisternal-Southern Administration.
Depolac in 1 ml as active substances of cloxacillin benzathine - 100 mg and neomycin sulfate - 50 mg, as well as auxiliary substances: benzyl alcohol - 10.4 mg and liquid paraffin up to 1 ml.
The drug is packaged in 5 ml plastic syringes dispensers, packaged in 24 pieces in cardboard boxes. Each single consumer packaging is supplied with instructions for use.
The supplier stores in the closed packaging of the manufacturer, in a dry, dark place, separately from food and feed at a temperature of 5 ° C to 25 ° C.
Depolak shelf life if storage conditions are observed is 2 years from the date of production.
Do not use the drug after the expiration date.
Depolak should be kept out of the reach of children.
Unused medication is disposed of in accordance with the requirements of the law and legislation.

PHARMACOLOGICAL PROPERTIES

Depolac is a complex antibacterial drug.
The combination of antibiotics - clincicillin, benzathine and neomycin sulfate, which are part of the medicinal product, which provides anti-bacterial action of Depolac against mastitis pathogens, includes the excretion of cows in the dry period, including Streptococcus species, Staphylococcus species, Clostridium species, including resistant to chilli, and resistant to chilli; the resistance of which is due to [3-lactamase.
Cloxacillin benzathine is an antibiotic from the group of semi-synthetic penicillins, active against some gram-positive microorganisms, including Corynebacterium pyogenes, Staphylococcus aureus (including penicillin-resistant forms), Streptococcus dysgalactiae and Streptococcus urber.
The mechanism of action of cloxacillin on a bacterial cell is a violation of the synthesis of the cell wall by inhibiting the process of formation of transpeptide bonds necessary for cross-linking peptidoglycan.
Neomycin sulfate is an antibiotic from the group of aminoglycosides, active against gram-negative bacteria, including Escherichia coli, Klebsiella spp., Pasteurella spp., Salmonella spp. and Staphilococcus spp.
The mechanism of bacterial action of neomycin sulfate is the binding of antibiotics to specific receptor proteins. The SCA subunit of ribosomes is bacterial cells that cause the accumulation of abnormal proteins and cessation of metabolism. Synthesized abnormal proteins, embedded in the cytoplasmic membrane, violate its structure and permeability, which leads to the death of microbial cells.
Deposit on the degree of impact on the body belongs to the moderately hazardous substances (3 hazard class according to GOST 12.1.007-76).

APPLICATION ORDER

Depolac is used for therapeutic and therapeutic purposes for cows with mastitis in the dry period.
Contraindications to the use of Deposits are individual hypersensitivity of the animal to the drug component, as well as severe functional disorders of the liver and kidneys. Depolac prohibits the use of cows during lactation, as well as depending on the allocation of antibiotics with milk.
Depression is applied depending on the degree of readiness, depending on whether it is a dry period, but not longer than 42 days before the expected calving, in a dose of 5 ml (1 syringe dispenser) in every quarter of the udder.
The introduction of an antiseptic solution. After this is done, the dosing unit is inserted into the nipple opening and gently presses on the piston, injecting the entire contents. After you understand that palm trees pinch nipples for 1-2 minutes, they spend a light massage for better distribution of the drug.
Symptoms of drug overdose have not been established.
Special actions at the first use and with the abolition of the drug are not identified.
The drug is administered one of them.
In accordance with this manual, as a rule, is not observed. In case of increased individual sensitivity, antihistamines are prescribed.
The use of Depolak does not preclude the use of other drugs for animals, except for drugs for intracisternic administration.
Allowed no earlier than 28 days after the last use of the drug. Animal meat should be used in feeding fur animals. Milk for food is allowed to use no earlier than 120 hours after calving. In case Depolak was mistakenly administered to lactating cows, or if the intended time had previously occurred, then